VDR is a gene that encodes a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene (rs2228570, FokI polymorphism) is associated with a decreased bone mineral density among prepubescent girls of white background.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern as well as the temporal on-and-off occupancy of VDRE between the two components. It is also controlled by chromosomal locations and binding preferences for specific hormones. Microarray studies of human cells reveal that over 100 genes have an identifiable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that https://www.gescheftmarketing.de/ can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository of data and documents that are relevant to legal, business transactions or other activities that have limitations on viewing and downloading. It makes use of a central computer and an extranet which is a restricted-access Internet connection that allows users to log on at specific times.
VDRs are used most often by investment banks and companies involved in mergers or acquisitions. They require to communicate information in a clear manner with potential investors or buyers. Due diligence processes will also require a significant amount of information. Life science companies also use VDRs to keep everything from clinical trial results to HIPAA documentation.